摘要
甲硫氨酰氨肽酶(MetAP)是潜在的抗细菌、抗真菌和肿瘤治疗的分子靶点。MetAP是一类两价金属离子依赖的蛋白水解酶。然而,生理状态下,MetAP在细胞内结合并利用的金属离子类型目前还没有定论。因而,研究和发展不同金属离子选择性的甲硫氨酰氨肽酶抑制剂对细胞内源性金属离子的解析以及新型抗肿瘤及抗感染药物的研发具有重要意义。
The methionine aminopeptidases (MetAPs) are promising targets for development of novel antibacterial, antifungal and anticancer agents. All MetAPs require a divalent metal ion for activity. However, its physiologically relevant metal ion remains to be defined. Therefore, the different metalloform-selective MetAP inhibitors could be valuable for defining which metals are physiologically important for MetAP activity and could serve as leads for development of new therapeutic agents.
出处
《生命科学》
CSCD
2006年第2期155-160,共6页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金(30271528)
上海市青年科技启明星计划(02QB14013)