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金属离子选择性的甲硫氨酰氨肽酶抑制剂研究进展

Progress in the studies of metalloform-selective methionine aminopeptidase inhibitors
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摘要 甲硫氨酰氨肽酶(MetAP)是潜在的抗细菌、抗真菌和肿瘤治疗的分子靶点。MetAP是一类两价金属离子依赖的蛋白水解酶。然而,生理状态下,MetAP在细胞内结合并利用的金属离子类型目前还没有定论。因而,研究和发展不同金属离子选择性的甲硫氨酰氨肽酶抑制剂对细胞内源性金属离子的解析以及新型抗肿瘤及抗感染药物的研发具有重要意义。 The methionine aminopeptidases (MetAPs) are promising targets for development of novel antibacterial, antifungal and anticancer agents. All MetAPs require a divalent metal ion for activity. However, its physiologically relevant metal ion remains to be defined. Therefore, the different metalloform-selective MetAP inhibitors could be valuable for defining which metals are physiologically important for MetAP activity and could serve as leads for development of new therapeutic agents.
出处 《生命科学》 CSCD 2006年第2期155-160,共6页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金(30271528) 上海市青年科技启明星计划(02QB14013)
关键词 甲硫氨酰氨肽酶 金属离子选择性 抑制剂 methionine aminopeptidase metalloform-selective inhibitor
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参考文献29

  • 1Lowther W T,Matthews B W.Structure and function of the methionine aminopeptidases.Biochim Biophys Acta,2000,1477(1-2):157~167.
  • 2Vaughan M D,Sampson P B,Honek J F.Methionine in and out of proteins:targets for drug design.Curr Med Chem,2002,9(3):385-409.
  • 3Griffith E C,Su Z,Turk B E,et al.Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.Chem Biol,1997,4(6):461~471.
  • 4Lowther W T,Orville A M,Madden D T,et al.Escherichia coli methionine aminopeptidase:implications of crystallographic analyses of the native,mutant,and inhibited enzymes for the mechanism of catalysis.Biochemistry,1999,38(24):7678~7688.
  • 5Tahirov T H,Oki H,Tsukihara T,et al.Crystal structure of methionine aminopeptidase from hyperthermophile,Pyrococcus furiosus.J Mol Biol,1998,284(1):101~124.
  • 6Liu S,Widom J,Kemp C W,et al.Structure of human methionine aminopeptidase-2 complexed with fumagillin.Science,1998,282(5392):1324~1327.
  • 7Oefner C,Douangamath A,D'Arcy A,et al.The 1.15A crystal structure of the Staphylococcus aureus methionylaminopeptidase and complexes with triazole based inhibitors.J Mol Biol,2003,332(1):13~21.
  • 8Bazan J F,Weaver L H,Roderick S L,et al.Sequence and structure comparision suggest that methionine aminopeptidase,prolidase,aminopeptidase P,and creatinase share a common fold.Proc Natl Acad Sci USA,1994,91(7):2473~2477.
  • 9Walker K W,Bradshaw R A.Yeast methionine aminopeptidase Ⅰ can utilize either Zn2+ or Co2+as a cofactor:a case of mistaken identity.Protein Sci,1998,7(12):2684~2687.
  • 10D'souza V M,Holz R C.The methionyl aminopeptidase from Escherichia coli is an iron(Ⅱ) containing enzyme.Biochemistry,1999,38(34):11079~11085.

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