锌粉催化合成N-烃基-3-氯丙胺

Synthesis of N-alkyl-3-chloride propylamines catalyzed by Zn powder

N-烃基-3-氯丙胺是重要的药物合成年口研究的中间体，此类化合物以前的合成方法存在着反应时间长、反应温度较高、收率较低的不足之处。我们对此类化合物的合成方法进行了改进，采用1-溴-3-氯丙烷和仲胺为原料，锌粉作催化剂，通过缩合反应得到产物，反应后的锌粉可再生利用。采用该方法合成N-烃基-3-氯丙胺，以仲胺计总收率可达67％-86％。该方法操作简便，收率较高，具有较高的经济价值。

N-alkyl-3-chloride propylamine is an important intermediate of medicinal synthesis and research. However, the disadvantages of previous procedures were longer reaction time, high temperature and low yields. We did some work to improve the procedures. N-alkyl-3-chloride propylamine was synthesized from 1-bromo-3-chloride propane and secondary amine as raw material using Zn powder as a reusable catalyst by condensation. The total yield reached 67 % ~ 86 % calculated by secondary amine. In conclusion the advantages of the present method are the simple operation and higher yields. These make the method economically valuable.