三苯氧胺与化疗联合应用治疗晚期恶性肿瘤临床观察

Combined Chemotherapy and Tamoxifen for Advanced Malignant Tumours

为探索三苯氧胺和化疗联合治疗恶性肿瘤的协同作用。对４０例晚期恶性肿瘤患者进行了随机分组对照试验。２０例采用三苯氧胺加化疗（实验组），２０例单纯化疗（对照组），两组化疗方案相同。初步结果显示，两组总有效率分别为７５％（１５／２０）和４５％（９／２０），两组疗效相比有显著性差异。毒副作用两组无显著性差异，未见三苯氧胺明显不良反应。表明三苯氧胺有化疗增敏剂之作用，有助于改善化疗效果。

A prospective randomized clinical trial in patients with advanced malignant tumour was carried out to evaluate the chemosensitizing effect of Tamoxifen.Between 1993 and 1994,40 patients were treated:20 by combination of Tamoxifen with chemotherapy(study group)and 20 by conventional chemotherapy alone(control group).Preliminary results showed that the response rates were 75% and 45% in the two groups respectively with statistically significant difference.Notable adverse reaction of Tamoxifen was not observed.This study may imply that rational administration of Tamoxifen could improve the treatment result.