恶性阻塞性黄疸患者减黄术前后免疫功能变化的研究

Immunity of Patients with MalignantObstructive Jaundice Pre-and Postoperatively

检测１８例恶性阻塞性黄疸患者减黄术前１天，术后１、３、７、１４和２１天免疫功能变化另设２０例良性阻塞黄疸患者为对照。结果显示：总补体、补体Ｃ３增高，ｓＩＬ－２Ｒ术后先上升后下降，而后又再次上升，表明减黄术对改善恶性阻塞性黄疸患者免疫功能有效。

In this study, the immunity of 18 patients with malignant obstructive janudice was gauged befor and after biliary drainage.Similar measurements of immunity were made on another 20 patients with benign obstructive jaundice as control.The results revealed that total complement and complement C3 were elevated with peak value on the 3rd post-operative day.No sognificant difference was discernable between these two groups of patients;Complement C4 level after bile duct drainage showed no marked change in both groups.Changes of soluble interleukin-2receptor(sIL-2R)and lymphocyte transformation rate(LTR) were alike with significantly higher content of sIL-2R in malignant group than in the benign group, the peak value being observed on the 3rd post-operative day and subsequently declined went up again on the 14th post-operative day in the malignant group.It Is suggested that drainage obstructive jaundice patients in terms of the T cell subset,complement and sIL-2R as markers.