脑转移瘤126例临床分析

Clinical Study on 126 Cases of Metastatic Brain Tumor

报道１２６例脑转移瘤的诊疗体会，其中以４０～６０岁最多见，占６９．１％，临床上多亚急性起病，出现颅内压增高及局灶症状。脑ＣＴ及胸部Ｘ线检查对诊断有重要价值。脑转移瘤的Ｋｉ６７标记指数（Ｋｉ－６７ＬＩ）及核仁组成区嗜银蛋白（ＡｇＮＯＲ）计数均最高，其数值远远超过任何颅内原发恶性肿瘤，是对病理学诊断重要的补充及参考。随访结果表明对脑转移后采用手术治疗加放疗效果最优，并提出多发转移灶的手术处理原则。

patients with metastatic brain tumor were treated in the Department of Neurosurgery during the last decade.The incidence was high in 40 to 60 years.Most of the patients had a subacute clinical course with increased intracranial pressure and localized symptoms and sings.The primary tumor was located in a descending order of lung,digestive system,breast,nasopharynx and female genital system.Brain CT scanning and chest X-ray examination play an importment role in the diagnosis of metastatic brain tumor.As compared to other types of brain tumor,metastatic brain tumor had the highest proliferative activity assessed by Ki-67 labelling index and silver staining of nucleoar organizer region.From the follow up study,it was found that the patients treated with surgery plus postoperative radiotherapy survived much longer than those with other modalities of treatment.