PAI-1蛋白在子宫内膜异位症组织的表达及意义

Expression and significance of plasminogen activator inhibitor-1 protein in endometriosis

目的:探讨PA I-1蛋白在异位内膜、在位内膜及对照组内膜的表达及意义。方法:应用免疫组化方法检测PA I-1蛋白在40例内异症组异位内膜及在位内膜,30例对照组子宫内膜的表达。结果:①PA I-1蛋白表达于异位内膜、在位内膜、对照组内膜的腺上皮细胞及间质细胞胞浆;②PA I-1蛋白在异位内膜及对照组内膜间质细胞表达均高于腺上皮细胞(P<0.05),而于在位内膜腺上皮细胞与间质细胞表达比较无统计学意义(P>0.05);③PA I-1蛋白在间质细胞表达异位内膜高于在位内膜及对照组内膜(P<0.05),而在腺上皮细胞表达异位内膜、在位内膜、对照组内膜三者之间比较无统计学意义(P>0.05);④PA I-1蛋白在血管内皮细胞呈阳性表达。结论:PA I-1蛋白在异位内膜间质细胞高表达可能促使其转移、黏附、侵袭、生长,导致子宫内膜异位症的发生发展。

Objective To investigate the expression of plasminogen activator inhibitor（PAI-1） in control endometrium, ectopic and eutopic endometrium with endometriosis. Methods Immunohistochemistry method was used to detect the expression of PAI-1 protein in 40 cases of ectopic endometrium, 40 cases of eutopic endometrium and 30 cases of endometrium without endometriosis. Results PAI 1 protein was expressed in stromal and epithelial cells from control endometrium, ectopic and eutopic endometrium with endometriosis. PAI-1 protein tended to be higher from stromal cells in ectopic endometrium and control endometrium than from epithelial cells （P〈 0. 05 ）, but there was no statistical difference between stromal cells and epithelial cells in eutopic endometrium （P〉0. 05）. Furthermore, the expression of PAI-1 was increased in endometriotic stromal cells compared with endometrial stromal cells （P〈0. 05）, but there was nostatistical difference in epithelial cells among control endometrium,ectopic and eutopic endometrium（P〉0. 05）. Conclusion The abnormal expression of PAI-1 protein might play an important role in the pathogenesis of endometriosis.