平滑肌肿瘤组织形态与预后的关系

Some Histological Factors, Expression of Proliferation Cell Nuclar Antigen and C-erbB-2 Oncogen Product as They Related with Smooth Muscle Tumor Prognosis

分析１５０例平滑肌肿瘤的随访资料。４６例ＬＭ中除１例死于其它原因外，余全部存活。１０４例ＬＳ术后逐年生存率为１年８４．６％，２年６９．２％，３年５７．７％，４年５３．８％，５年５０．０％。ＬＳ预后与核分裂数、细胞形态、细胞密度及细胞异形性四项形态学指标均有关，其中核分裂数与预后关系最为密切。免疫组化检测结果显示：①ＰＣＮＡ及ｃ－ｅｒｂＢ－２的表达与ＬＳ预后有密切关系。②ＰＣＮＡ的表达与核分裂数、细胞形态及细胞异形性有关。③ｃ－ｅｒｂＢ－２的表达与核分裂数及细胞异形性有关。提示这二项检测方法是估计ＬＳ预后的可靠手段。

The follow-up data of 150 patients with smooth muscle tumors were analysed. Except one patients with leiomyomas survived.Of 104 leiomyosarcomas(LS)84.6%survived for 1 yrs,69.2% for 2yrs,57.7% for 3 yrs,53.8% for 4 yrs,and 50% for 5yrs after operation,respectively.The prognosis of LS are related with four morphology indexes,including mitotic figures,cellular polymorphism cellularity,and atypism.Mitotic figures were most related.Immunohistochemical staining Showed that: 1)the expression of PCNA as well as c-erbB-2 correlated closely with prognosis of LS,2)the expression of PCNA was associated with mitotic figore,0cellular polymorphism and atypism,3)the expression of c-erbB-2 corelated with mitotic figure and atypism.It is suggested that these two parameters may be used in the evaluation of prognosis of LS.