摘要
报道了N_1′-甲基靛玉红肟的合成、晶体结构及性质.体外美蓝试验结果表明,它的抗白血病活性明显优于靛玉红,其水溶性和脂溶性都较靛玉红有所增强.用X射线衍射法测得其晶体结构,组成为C_(17)H_(13)N_3O_2,N_r=291.21,空间群P2_1/c,晶体学数据:a=1.5226(4),b=0.6524(3),c=1.6562(5)nm;β=103.69(4)°,Z=4.最终偏离因子为0.043.分子近似平面型.
In this paper the synthesis,crystalline structure and properties of N_1′-methyl in-dirubin monooxime(MIM)are reported.The antileukemic activity was determined by themethylene blue method in vitro and proved to be better than that of indirubin clearly. Its wa-ter-solubility and fat-solubility power are better than those of indirubin, Crystalline structure of MIM was determined by X-ray diffraction method.The crystalline composition C17H13N_3O_2,M_r=291.21.The crystal is monoclinic,space group P2_1/c, with a=1.5226(4) nm,b=0. 6524(3)nm,c=1.6562(5) nm:β=103.69(4)°,Z=4.The final deviation factor R=0.043.The molecule is approximately planar.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1996年第1期69-72,共4页
Chemical Journal of Chinese Universities
关键词
甲基靛玉红肟
抗白血病活性
分子结构
青黛
N_1′-Metliyl indirtibin monooxime, Antileukemia/activity, Molecular structure,Crystalline structure, Structtire-activity relationship