1－苯基－3－甲基－5－吡唑啉酮与二羰基化合物的固相反应研究

Studies on Solid State Reaction of 1-Phenyl-3-methyl-5-Pyrazolone with Dicarbonyl Compounds

报道了苯偶酰及其衍生物、对二甲氨基苯偶姻、邻苯二甲酰亚胺与１－苯基－３－甲基－５－吡唑啉酮的固相热反应研究；这个热反应以较高的选择性生成１：１缩合产物的一种异构体，通过ＩＲ、１ＨＮＭＲ、ＭＳ和元素分析确定了新产物的结构，并通过Ｘ射线衍射分析确定了其中一个产物的构型．

The solid state reactions of benzil,p-dimethylaminobenzil,4,4′-dibromobenzil,p-dimethylaminobenzoin and o-phthalimide with 1-phenyl-3-methyl-5-pyrazolone were re-ported. This thermal reaction was carried out at 120℃ for 0.5hand gave one of the 1:1condensation isomers in a higher selectivity. The structures of seven new products wereidentified by IR,1HNMR, MS and elementary analysis, and the configuration of the prod-uct 1-phenyl-3-methyl-4-benzoylphenylmethylene-5-pyrazolone 1 was determined by X-raydiffraction analysis. In the molecule of compound 1, there is four plans rather than coplanar.Benzoyl group and CO group of five membered ring are in cis-positions, the interaction ofoxygen atoms leads to noncoplanar.