3-氯-2-羟丙基脲的合成

Synthesis of 3-Chloro-2-hydroxypropylurea

用环氧氯丙烷和尿素制备了一种反应中间体3-氯-2-羟丙基脲。研究了反应温度、反应时间、环氧氯丙烷与尿素的用量比、氧氧化钠的用量对氯离子的生成率和产物环氧值的影响。结果表明：当温度为80～90℃，反应时间为120min，V[w（尿素）=50％]／V（环氧氯丙烷）=1．92，c（NaOH）=0．05mol／L的水溶液14mL时，所得产物的环氧值和氯离子生成率都比较小，产物以3-氯-2-羟丙基脲为主。

3-Chloro-2-hydroxypropylurea was synthesized by reaction of urea with epichlorohydrin. Under the optimized reaction conditions, 10 mL epichlorohydirn was dropped into a mixture of 19. 2 mL 50% urea and 14 mL 0.05 mol/L NaOH at 80 - 90 ℃ and reacted for 120 rain. Chloride ion and epoxy number in the product are small. The product is basically 3-chloro-2-hydroxypropylurea.