聚氧乙烯大单体与甲基丙烯酸甲酯的共聚合及其共聚物的研究

Studies on Copolymerization of Poly (ethylene oxide )Macromer and Methyl Methacrylate with Their Copolymers

研究了聚氧乙烯（ＰＥＯ）大单体与甲基丙烯酸甲酯的溶液共聚合，考察了引发剂用量、单体总浓度、投料比、反应时间对共聚物组成和分子量的影响．ＩＲ、￣１ＨＮＭＲ、ＧＰＣ、ＶＰＯ、ＤＳＣ及透射电镜等测定结果表明，经纯化的共聚物具有预期的结构，且呈现微相分离．体外人体正常抗凝血浆复钙时间测定结果显示：共聚物的抗凝血性明显好于玻璃和ＰＭＭＡ均聚物，且随共聚物中ＰＥＯ含量的增加而增强，经水化处理的共聚物的抗凝血性比未经处理的好．

Copolymerization of a-methacryloyl-ω-poly(ethylene oxide)(PEO)macromers with methyl methacrylate(MMA)in toluene using AIBN as initiator was studied.The effects of amount of initiator,total monomer concentration,reaction time and chargingratio of the macromer to MMA on the composition and molecular weight of the graft copolymer were studied.The purified copolymer was characterized with IR,1H NMR,DSC andGPC. Microphase separated structure of the copolymer was observed with TEM and the an-tithrombogenic properties were evaluated.