共轭亚油酸异构体对人类癌细胞增殖的抑制作用研究

Inhibiton of conjugated linoleic acid isomers on the proliferation of tumor cells

目的研究不同共轭亚油酸对人类胃癌细胞AGS、肝癌细胞Bel7402和肠癌细胞Lovo细胞增殖的影响。方法采用体外培养的AGS、Bel7402和Lovo细胞为模型,测定不同处理后活细胞数量。结果研究采用的5种共轭亚油酸异构体都对AGS、Bel7402和Lovo细胞增殖表现出了抑制作用,对AGS的抑制作用要普遍高于对Bel7402和Lovo的抑制作用,并且浓度不同,抑制作用也具有差异。结论五种共轭亚油酸异构体都具有抑制癌细胞增殖的作用,并且这种作用受到共轭亚油酸浓度的影响。

Objective To study the effect of five conjugated linoleic acid isomers on the proliferation of human tumor cell AGS and Bel7402. Methods AGS, Bel7402 and Lovo cells incubated in vitro were used as model. The cell visibility was investigated after treatment with conjugated linoleic acid（CLA）. Results All the five isomers had inhibitory ability to AGS, Bel7402 and Lovo cell proliferation, and the effect on AGS was more effective than that on Bel7402 and Lovo. The inhibitory effect was dose-dependent. Conclusion The five isomers of CLA exhibited proliferation inhibitory effect on the tumor cell of AGS and Bel7402.