利用散射系数变化测量血糖浓度的研究

A Study of Blood Glucose Concentration Measurement by Scattering Coefficient

论述了血糖浓度变化与溶液的散射系数的关系。在浑浊介质中散射特性取决于散射粒子和溶剂的折射率的相对大小,在血液中葡萄糖浓度的改变会引起血液折射率的变化,从而使血液的散射系数发生改变,从理论上给出了血糖浓度变化时计算散射系数变化的公式,得出了散射系数和血糖浓度成正比的结论。进一步讨论了满足临床应用目标下,散射系数的相对变化的测量精度要达到4.8×10-4,而对于中国人的血液绝对测量精度要达到6.82×10-3mm-1。用双积分球实验验证了理论计算的正确性,使用牛奶作为浑浊介质测量其散射系数与糖浓度的关系,在不同波长下散射系数都随葡萄糖浓度改变而改变,且线性度可以达到0.95以上。由此可以得出结论,血糖浓度可以通过测量散射系数来得到。

The relationship of scattering coefficient and concentration of blood glucose is discussed. The scattering coefficient of turbid media is determined by the relative refractive index of scattering particles to solvent. The variation of blood glucose concentration changes the refractive index of blood, and the scattering coefficient of the blood. It is given that the formuta to calculate the variation of scattering coefficient induced by concentration change of blood glucose concentration based on theoretical analysis, which shows that the scattering coefficient is directhy proportional to the blood gloucose concentration. The measurement accuracy of scattering coefficient relative change should attain 4.8 × 10^-4 to satisfy the requirement of clinical use, and for Chinese, the absolute measurement precision must be higher than 6.82 × 10^-3 mm^-1. Double integrating sphere experiment is used to validate the theory. Milk is used as turbid media to observe the relationship of scattering coefficient and glucose concentration. At every wavelength the scattering coefficients are linearly changed with the glucose concentration and the linearity value is higher than 0.95. The theoretical analysis and the experimental result prove that blood glucose concentration can be measured by scattering coefficient.