细菌耐药性变异与抗菌药用药3年统计分析

Statistical Analysis of the Variation of Drug Resistance and the Frequency of Anti-bacterial Usage from 2002 to 2004

目的:探讨细菌耐药性变异与抗茼药用药频度(DDDs)的相应关系。方法:对我院22种抗茼药连续3年的DDDs作统计和排序;同期对部分致病菌进行年度耐药率统计,并进行相关结果比较。结果:细菌产生高度耐药的抗菌药品种,正是历年来DDDs值高且排序列前的品种。第三代头孢菌素中多个品种DDD8排序列前,细菌对各品种产生了严重的交叉耐药,耐药率增高。铜绿假单胞菌(PA)和嗜麦芽寡养单胞菌(SM)的耐药现状最为严重。万古霉素的DDDs及排序变幅很小,耐药变异也小,对MRSA、MRCNS仍保持高敏性。结论:抗菌药的用药频度,即抗菌药应用的选择性压力,是影响细菌耐药性变异最主要的因素之一。

Objective： To study the relationship between the variation of drug resistance and the frequency of anti-bacterial usage （ODDs）. Method： The ODDs of 22 antibacterial drugs in our hospital during the three years were statistically recorded and sequenced, the synchronic annual resistant rates of some pathogenic bacteria, collected and their related results, compared. Result： The anti-bacterial drugs with high resistance were the kinds that had their high values of DDDs and were sequenced in the front in the past years. The bacteria had serious cross resistance to many of the third generation of cephalosporins, and their resistance rates were high. The resistance situation of PA and SM were the most serious. For its DDDs varied slightly and had its small variation of drug resistance, vancomycin still remained its high sensitivity to MRSA and MRCNS. Conclusion： The DDDs, that is the selective pressure of the antibacterial usage, is one of the main influencing factors of the variation of drug resistance.