原发性肺癌肿瘤组织染色体变异比较基因组杂交分析

Chromosome Analysis of Primary Lung Cancer Using Comparative Genomic Hybridization

目的:分析原发性肺癌肿瘤组织染色体异常变化,了解肺癌组织染色体畸变规律。方法:应用比较基因组杂交技术分析55例原发性肺癌患者肿瘤组织染色体。结果:原发性肺鳞癌常见染色体扩增区是2q、5p、11q、22q,常见缺失区是1p、4q、5q、6q、8p、9p、10q、11p、13q、18q、21q。肺腺癌常见扩增区是5p、8q、11q,常见缺失区是10p、19。腺鳞癌、肺泡细胞癌、小细胞癌等染色体变化各有不同。结论:原发性肺癌存在广泛的遗传物质不平衡现象,不同病理分型的染色体基因扩增和缺失可能是其发生、发展的基础。

Objective： To analyze the unbalanced state of hereditary material of squamous cell carcinoma, adenocarcinoma and other types of lung cancer and to provide data for study of the mechanism of lung cancer. Methods： Fifty-five patients suffered from lung cancer were included in this study. The technology of comparative genomic hybridization （CGH） was used. Results： The common extension regions of squamous carcinoma were 2q, 5p, 11q and 22q. The common deletion regions were lp, 4q, 5q, 6q, 8p, 9p, 10q, 11p, 13q, 18q and 21q. The common extension regions of adenocarcinoma were 5p, 8q and 11q. The common deletion regions were 10p and 19. Conclusion： The hereditary material of lung cancer is unbalanced. The extension and deletion of chromatosome are the base of the occurrence of different lung cancer.