无精或严重少弱精症与雄激素受体基因重复多态性的关系

Study on the polymorphism of (CAG)n repeats within androgen receptor gene in severe oligozoospermia or azoospermia patients

目的：探讨无精或严重少弱精症患者与雄激素受体基因（CAG）n重复多态性的关系。方法：应用DNA双链循环测序方法，对32例无精或严重少弱精症患者（不育组）、15例正常生育男性（对照组），进行外周血雄激素受体基因（CAG）n重复数的测定。结果：不育组32例患者（CAG）n重复数为17～25，平均21．08±2．1；对照组15例为11～27，平均21．2±2．3。两者比较差异无统计学意义。结论：无精或严重少弱精症患者与雄激素受体基因（CAG）n重复数的没有关系。

Objective：To study the relationship between polymorphism of （CAG）n repeats within androgen receptor gene with severe oligozoospermia or azoospermia patients. Methods：32 severe oligozoospermia or azoospermia patients and 15 health controls were assessed （CAG）n repeats by dsDNA cycle sequencing. Results：The number of （CAG）n repeats of 32 patients was 17-25 with the mean of 21.08-2.1 ; whereas 15 health men was 11- 27 with the mean of 21.2±2.3. No significant difference in the the polymorphism of （CAG）n repeats in androgen receptor gene was found between two groups （ P 〈0.05）. Conclusions： No significant increased length of （CAG）n repeats in androgen receptor gene is found for severe oligozoospermia or azoospermia patients.