生长激素/胰岛素样生长因子Ⅰ轴和运动

Growth hormone/insulin-like growth factor-Ⅰ axis and exercise

目的:综合分析运动和生长激素/胰岛素样生长因子Ⅰ轴的关系。资料来源:应用计算机检索Medline1990-01/2005-05有关运动、生长激素/胰岛素样生长因子Ⅰ轴的文献,检索词“GH、insulin-likegrowthfactor-Ⅰ、exercise”,限定文章语言种类为English。资料选择:共检索到180篇文献,对资料进行初审,选择运动与生长激素/胰岛素样生长因子Ⅰ轴关系的文章,包括动物实验和人体实验。排除重复研究。资料提炼:经过分析选取34篇文章,其中12篇符合纳入标准作为参考文献,排除22篇重复文章。资料综合:一次急性运动后人血中生长激素浓度即刻显著升高,而循环中的胰岛素样生长因子Ⅰ浓度升高不大或不变。耐力运动或长期的力量练习增加运动中和安静时生长激素/胰岛素样生长因子Ⅰ轴的活性,但各研究结果不同。抗阻力训练对训练后安静状态下的生长激素水平无明显影响,而耐力运动员安静状态下的血清胰岛素样生长因子Ⅰ浓度高于一般正常人。目前有关运动与生长激素/胰岛素样生长因子Ⅰ轴的关系还不完全明了。结论:生长激素/胰岛素样生长因子Ⅰ轴与运动关系密切。运动可以影响生长激素/胰岛素样生长因子Ⅰ轴各激素的血清水平,生长激素/胰岛素样生长因子Ⅰ轴的活性能够影响运动能力。目前运动影响生长激素/胰岛素样生长因子Ⅰ轴的作用途径仍是研究热点。

OBJECTIVE： To analyze the relationship between exercise and the growth hormone （GH）/insulin-like growth factor- Ⅰ （IGF- Ⅰ ） axis. DATA SOURCES： The relevant articles about sport, GH and IGF- Ⅰ axis published between January 1990 and May 2005 were searched in Medline with the keywords of ＂GH, insulin-like growth factor- Ⅰ, exercise＂ in English. STUDY SELECTION： Totally 180 literatures were retrieved. After primary search of data, the articles about the association between exercise and the growth hormone/insulin-like growth factor- Ⅰ axis were selected, including the study of both animal experiment and human basic research. Articles on repeated experiments were excluded. DATA EXTRACTION： After analyzing, totally 34 articles were collected, Among them, 12 papers were included as references and 22 papers were excluded duo to repeated experiments. DATA SYNTHESIS： After acute exercise the concentration of GH had been markedly increased immediately and the circulating IGF-Ⅰ levels only slightly increased or no change, Endurance exercise and chrinic strength exercise increased the activity of the GH/IGF- Ⅰ system both at rest and during exercise, but there were some discrepancies among some studies. Resistance training did not apparently affect resting concentrations of GH, whereas resistance-trained men had been shown to have higher resting IGF-Ⅰ concentrations than untrained men. The relationship between exercise and GH/IGF- Ⅰ axis was incompletely clear at present. CONCLUSION： GH/IGF-Ⅰ axis has a very close relationship with exercise. Exercise can affect the serum level of the hormones in the GH/ IGF-Ⅰ axis, The activity of GH/IGF-Ⅰ axis can affect the exercise performance. The mechanism by which exercise affects activity of the GH/ IGF- Ⅰ axis is still the key point of research.