口腔负压改善紧张性头痛患者微循环障碍20例(英文)

Oral negative pressure in amelioration of tension headache in 20 patients with microcirculation disturbance

背景:紧张性头痛指双侧枕颈部或全头部的紧缩性或压迫性头痛,其发病机制尚未完全明了,可与多种因素有关,常规治疗是药物对症疗法,但疗效不一,特别是慢性患者,长期服药引起副作用。目的:探讨口腔负压对紧张性头痛患者的治疗效果及其微循环障碍改善机制。设计:病例-对照观察。单位:河北北方学院病理生理教研室。对象:于2001-12/2002-06河北北方学院附属第一医院神经内科收治紧张性头痛患者20例,男8例,女12例;年龄18～28岁,平均23.4岁;病程1～6年。随机分为治疗组和对照组,各10例。方法:应用口腔负压仪,将负压施加器放入口腔的最适位置,调节负压维持在(0.05±0.01)MPa。治疗时间10min/次(首次应用治疗5min),1次/d,时间固定,5d为1个疗程,共3个疗程。对照组同样口含负压施加器10min/次,但不给负压。①疗效判断标准:采用目测类比评分法进行疼痛量化评估,显效:视觉模拟评分下降>70%,有效:下降30%～70%,无效:下降<30%。②甲襞微循环观察与评价:应用XTL-Ⅱ型微循环显微电视系统进行甲襞微循环观察,放大260倍,常规检查左手无名指甲襞第一排管袢,记录微血管形态、微血流状态和袢周状态,按田牛等加权积分法对微循环障碍程度进行定量分析。主要观察指标:治疗3个疗程后的治疗效果,甲襞微循环观察结果。结果:纳入患者20例,均进入结果分析。①治疗效果:目测类比评分下降>70%治疗组7例(70%),对照组0例;目测类比评分下降30%～70%治疗组2例(20%),对照组1例(10%);目测类比评分下降<30%治疗组1例(10%),对照组9例(90%)。②治疗前后甲襞微循环观察表明,负压使微循环障碍明显改善,由治疗前的中度异常恢复到大致正常,总积分值由4.18±0.68降低至1.97±0.41(P<0.01)。结论:口腔负压对紧张性头痛患者具有明显的治疗效果,其机制可能与改善微循环及调整神经功能紊乱有关。

BACKGROUND： Tension headache means contraction headache or oppressive headache in bilateral occipital-cervical part or whole head. Its pathogenesy has not been completely known yet, which may be related to many factors and the conventional therapy is drug heteropathy but the effects are different, especially on patients with chronic disease and side effects will be induced by long-time intake of drugs. OBJECTIVE： To explore the curative effect of oral negative pressure on patients with tension headache and its mechanism of ameliorating microcirculation disturbance. DESIGN： Case-control observation. SETTING： Department of Pathophysiology of Hebei North University. PARTICIPANTS： Twenty patients with tension headache in the Department of Neurology, First ,Affiliated Hospital of Hebei North University from December 2001 to June 2002 including 12 females and 8 males, aged 18-28 （mean 23.4） with the disease course of 1-6 years, were randomly divided into therapeutic group and control group with 10 patients in each group. METHODS： The oral negative pressure instrument was applied. Put the negative pressure exerting equipment in the optimal position of mouth, adjusted the negative pressure to （0.05±0.01） MPa. The therapeutic time was 10 minutes each time （5 minutes for the first time） once a day with the time fixed. There were 5 days in one course and totally 3 courses. Put the negative pressure exerting equipment into mouth of patients in the control group for 10 minutes each time without exerting negative pressure. Quantitative evaluation on pain was performed with visual analogue scale （VAS） method, excellent as the VAS score decreased above 70%, effective as the VAS score decreased between 30% and 70%, invalid as the VAS score decreased below 30%. XTL- Ⅱ type microcirculation micro-television system was used to observe the changes of nailfold microcirculation by magnifing 260 times. The first row nailfold of left ring figure was checked conventionally, state of microvessel, micro-bloodstream and peri-loop were recorded and degree of microcirculatory disturbance was quantitatively analyzed according to TianNiu＇s weighing integral method. MAIN OUTCOME MEASURES： The therapeutic effect after three courses and results of microcirculation observation. RESULTS： Totally 20 included patients were involved in the analysis of results. VAS scores of 7 patients in the therapeutic group decreased above 70% （70%）, while no patient in the control group; VAS scores of 2 patients in the therapeutic group decreased from 70% to 30% （20%） and one patient in the control group （10%）; VAS scores of one patient in therapeutic group decreased below 30% （10%） and nine patients in the control group （90%）. Negative pressure could obviously ameliorate the microcirculation disturbance and enable it to recover from moderate before treatment to nearly normal with the total score decreased from （4.18±0.68） points to （1.97±0.41） points （P 〈 0.01）. CONCLUSION：Oral negative pressure has a significant curative effect on patients with tension headache. Its mechanism may relate to the improvement of microcirculation and the adjustment of nervous functional disturbance.