高血压并发症与患者血清可溶性CD40及CD40L水平的关系

The association between hypertensive complications and serum levels of soluble CD40/CD40L in patients with cardiovascular diseases

目的探讨原发性高血压患者可溶性CD40/CD40L水平变化。方法根据WHO关于高血压器官损伤并发症的分类,将研究对象分为无并发症组、中度器官损伤及重度器官损伤组。应用酶联免疫反应法测定328名研究对象血清可溶性CD40(sCD40)及可溶性CD40L(sCD40L)水平。结果①与无并发症组(n=180)相比,sCD40水平在重度器官损伤组(n=50)显著升高(39.9±2.6vs30.0±1.0)ng/m l,P<0.01;与中度器官损伤组(29.4±1.4)ng/m l,(n=98)比较,重度器官损伤组sCD40水平也显著升高(P<0.01);②与无并发症组相比,重度器官损伤组中血清sCD40水平仅在中风组上调;③sCD40L在各组均无显著变化。结论血清sCD40/sCD40L水平与高血压并发症的严重程度有关。

AIM To investigate the changes sion. METHODS In a hospital-based and of soluble CD40/CD40L in patients with essential hypertencross-sectional study, we evaluated organ damages due to hypertension according to the World Health Organization （WHO） classification, including no complications, mild organ damages and severe organ damages. Serum soluble CD40 （sCD40） and soluble CD40L （sCD40L） levels were analyzed by commercially available ELISAs （Bender Med Systems, USA） in 328 patients. RESULTS Our main findings were： ①sCD40 was significantly increased in severe organ damage （39.9 ± 2.6） ng/ml, （ n = 50） versus no complication （ 30.0 ± 1.0） ng/ml, （ n = 180）, P 〈 0.01 and mild organ damage （ 29.4 ± 1.4） ng/ml, （ n = 98 ）, P 〈 0.01, respectively ; however, no significant changes in the sCD40 were measured in mild organ damages; ②when evaluated in severe organ damages group, serum sCD40 tended to be up-regulated in patients with stroke compared with controls （33.5 ± 2.6） ng/ml, （n =97）, P 〈0.05; ③sCD40L didn＇t exhibit significant results in our study groups. CONCLUSION Our findings may suggest that the association between chronic inflammation and hypertension by observing the serum soluble CD40/CD40L levels and hypertensive complications can indicate some inflammatory state.