中药熏蒸对强直性脊柱炎患者活动功能的影响

The effect of the traditional Chinese medicine fumigating to the activity of the patients with the ankylosing spondylitis

目的:研究中药熏蒸和常规的治疗方法对强直性脊柱炎患者活动功能的影响。方法:本组50例AS患者,中药熏蒸加柳氮磺胺吡啶(SASP)治疗组29例,其中男25例,女4例;平均年龄28.4岁;平均病程7.25±3.54年。单用SASP治疗组21例,男性20例,女性1例;平均年龄31.1岁;平均病程5.15±1.16年。治疗前根据国际通用的毕氏强直性脊柱炎功能指数(BASFI)表[2]计算两组患者的病情活动指数和功能指数。同时测定炎性指标的改变如血沉(ESR)、C反应蛋白(CRP)等;并进行药物安全性实验室检测。结果:两组患者病情活动指数和功能指数(除不扶物站立外)均较治疗前有明显改善(P<0.01或P<0.05),治疗后两组患者病情活动指数评分中,身体疲倦程度与关节僵硬程度之间存有显著性差异(P<0.05),而除关节疼痛程度与关节僵硬时间两组之间无显著性差异(P>0.05)。结论:中药熏蒸疗法对于改善患者身体的活动功能具有重要的意义,值得在临床上进行推广应用。

Objective：To study the clinical results of both the traditional Chinese medicine fumigating and the routine method in treating the activity of the patients with ankylosing spondylitis. Methods：50 cases with AS were enrolled. There were 29 cases in the group with the Chinese medicine fumigating with SASP, of which 25 were males and 4 were females. The average age were 28.4 years, and the mean disease course were 7.25±3.54 years. There were 21 cases in the Group with SASP only, of which 20 were males, and one was female. The average age were 31.3 years, and the mean disease course were 5.15 ± 1.16 years. The activity of the pathogenetic condition and the function index were measured with the BASFI table. The ESR and the CRP were simultaneous determined and the drug safety was also monitored. Results：There were improvement of the activity of the pathogenetic condition and the function index in both groups （P〈 0.01 or P〈0.05） . There were significant different in the indexes like the fatigue extent and the anchylosis extent （P〈0.05） in the two groups after treatment. Conclusions：The traditional Chinese medicine fumigating could play an important role in improving the activity ability of the patients with ankylosing spondylitis and worthy of spreading in the clinical practice.