氟比洛芬酯复合芬太尼术后镇痛的临床观察

Effect of flurbiprofen axetil with fentanyl for postoperative patient controlled analgesia

目的观察氟比洛芬酯复合芬太尼用于术后静脉自控镇痛的有效性和不良反应。方法择期腹部手术患者50例,手术结束后随机分为两组:对照组术毕静脉注射芬太尼0．1 mg为负荷剂量后接PCA泵,泵内药物为芬太尼1．2 mg、氟哌利多5 mg,100 ml·48 h-1;实验组术毕静脉注射氟比洛芬酯50 mg为负荷剂量后接PCA泵,泵内药物为氟比洛芬酯50 mg+芬太尼0．5 mg+氟哌利多5 mg,100 ml·48h-1。记录术后24 h内镇痛评分(VAS)、镇静评分(SS)及不良反应。结果两组镇痛效果的差异无统计学意义(P>0．05),对照组镇静度和恶心呕吐的不良反应明显高于实验组 (P<0．05)。结论氟比洛芬酯复合芬太尼用于术后静脉自控镇痛,可减少芬太尼的不良反应,提高镇痛质量。

Objective To investigate the efficacy and safety of flurbiprofen axetil combining with fentanyl for postoperative patient controlled analgesia（PCA）. Methods 50 patients undergoing scheduled abdominal surgery were randomly devided into two groups. In control group （ fentanyl 1.2 mg ＋ droperidol 5 mg/100 ml） ,the loading dose was fentanyl 0. 1 mg prior to the PCA;treatment group（ flurbiprofen axetil 50 mg ＋ fentanyl 0. 5 mg ＋ droperidol 5 mg/100 ml） ,the loading dose was flubiprofen axetil 50 mg prior to the PCA. The VAS and SS scores were evaluated in 24 hour after treatment. Results There was no significant difference in VAS between two groups （ P 〉 0. 05 ）. The SS scores, nausea and vomiting in control group were significantly more than that in treatment group（ P 〈 0. 05 ）. Conclusion Co-administration of flurbiprofen axetil with fentanyl by PCA offers overall favorable analgesic responses.