放疗同时化疗治疗晚期宫颈癌的临床观察

Evaluation of short-term efficacy of chemotherapy combined with radiotherapy in advanced cervix cancer

目的：观察放化同步治疗晚期宫颈癌的近期疗效及急性毒副反应.方法：初次治疗的Ⅲb期宫颈癌患者50例,随机分为单放组和放化组各25例.放疗采用加速器体外照射＋192Ir腔内后装治疗,体外剂量50Gy/25f/5w（30Gy时中央挡铅）,腔内照射A点总剂量42Gy/6f.化疗方案：PDD 30mg,d1～d4,静滴,5-FU 750mg,d1～d5,静滴,共2周期.结果：单放组CR为40.0%,PR为24.0%;放化同步组CR为68.0%,PR为24.0%（P＜0.05）.两组总有效率单放组68.0%,放化组92.0%（P＜0.05）.放化疗期间的不良反应,单放组骨髓抑制和胃肠道反应都较轻,而放化同步组较单放组重.结论：放化疗联合应用能提高晚期宫颈癌局部控制率,同时放化疗的急性反应也有增加,但这些反应是可逆的,而且对骨髓无严重毒性反应,患者均能耐受.

Objectlve：To evaluate the short-term efficacy and acute toxicity of chemotherapy combined with radiotherapy in advanced cervix cancer. Methods： 50 patients with stage Ⅲ b cervix cancers were randomized into observation group （ chemotherapy plus radiotherapy group） and sole radiotherapy group. Radiotherapy in both groups was administered with one-daily external irradiation doses of 2Gy to the pelvis, 5d/wk and brachytherapy to deliver a total dose of 42Gy to point A. Chemotherapy method were cisplatin 30mg, d1 - d4 ; 5-FU 750mg, d1 - d5 , for two cycles. Results：The total effective rate was higher in observation group than that in the sole radiotherapy group（ P 〈 0. 05 ）, Acute toxicity reaction increased in observation group but was tolerable. Conclusion：Chemotherapy combined with radiotherapy may improve the short-term therapeutic efficacy of advanced cervix cancer and the patients can endure the side effects.