厌氧菌性角膜炎

Anaerobic keratitis

厌氧菌所致的感染已经引起医学界的普遍关注,眼部厌氧菌感染也屡有报道。厌氧菌性角膜炎临床表现无特异性,而常规细菌培养不生长,对常用的氟喹诺酮类抗生素耐药,因此,此类细菌感染应该引起眼科医生重视。就厌氧菌性角膜炎的病原、流行病学、病理机制、临床表现及诊断治疗作一综述。

Infections caused by anaerobes have aroused a lot of interest in medicine, and ocular infections related to anaerobes are reported occasionally. Tsutsui reported the first case of anaerobic keratitis in 1957. According to the reported cases by now, Propionibacterium is the most common pathogen. Almost all of the cases have risk factors such as ocular disease, eye surgery, injury, topical use of corticosteroids and wearing of contact lens. The clinical situation of anaerobic keratits is of no specificity, and bacterial culture is of great important for diagnosis. But the culture of anaerobes often shows a negative result, so this kind of infectious keratitis can often be misdiagnosed as non-infectious keratitis. Anaerobes are resistant to fluoroquinolones. Ophthalmologists should pay more attentions to this type of keratitis. The pathogenesis, epidemicity, mechanism, clinical manifestation, diagnosis and treatment of anaerobic keratitis are reviewed.