摘要
目的探讨包头市汉族寻常型银屑病患者与HLA-DRB1*07等位基因的相关性。方法采用聚合酶链反应-序列特异引物(PCR-SSP)法,检测60例寻常型银屑病患者及80名健康对照者的等位基因频率,并相互比较。结果①HLA-DRB1*07与包头市汉族寻常型银屑病患者具有明显的相关性(P<0.01,OR=2.72)②HLA-DRB1*07在Ⅰ型、Ⅱ型寻常银屑病患者中分布无差异(χ2=0.16,P>0.05)。结论HLA-DRB1*07可能是寻常型银屑病易感基因或与易感基因相连锁。
Objective:To study the interrelationship between HLA-DRB1 * 07 allele and genetic susceptibility to psoriasis vulgaris(pv) in the Hart nationality in Baotou. Methods: With high-resolution polymerase chain reaction amplification with sequence specific primers(PCR - SSP), we detected the distribution frequencies of HLA- DRB1 * 07 allele among 60 cases with pv and 80 healthy controls and compared. Results: ① HLA- DRB1 * 07 allele was markedly correlated with psoriasis vulgaris from Baotou ( P 〈 0.01 , OR = 2.72 ) ; ② There is no difference of distribution between cases with typeI and typelI psoriasis vulgaris ( X^2 = 0.16 P〉0.05). Conclusion : HLA - DRB1 * 07 may be a susceptible gene or it may have close link with the susceptible gene in psoriasis vulgaris.
出处
《泰山医学院学报》
CAS
2005年第4期292-294,共3页
Journal of Taishan Medical College