急性脑梗死患者血浆组织因子及血栓调节蛋白的研究

Study on concentration of tissue factor and thrombomodulin in acute cerebral infarction patients

目的通过对急性脑梗死患者血浆中组织因子(Tf)及血栓调节蛋白(Tm)浓度的测定,了解Tf及Tm与急性脑梗死间的关系,以及与脑梗死相关因素间的关系。方法选择急性脑梗死患者76例,于发病后72h内取血,分别测定血浆Tf和Tm浓度,同时选择年龄、性别匹配的47例健康者做对照。采用SPSS11.5软件包进行统计分析。结果急性脑梗死患者血浆Tf为(384.06±179.68)pg/ml,明显高于对照组的(83.25±32.98)pg/ml(P<0.01);Tm为(2.899±2.901)ng/ml,明显低于对照组的(3.921±1.384)ng/ml(P<0.05)。在急性脑梗死组中1个系统单发组Tf为(300.15±139.17)pg/ml,2个系统多发组Tf为(417.61±209.43)pg/ml,程度重者Tf浓度明显增高(P<0.01);而1个系统单发组Tm为(3.177±2.399)ng/ml,显著高于2个系统多发组的(2.709±1.882)ng/ml(P<0.05);既望有脑血管病史组的Tm为(7.589±1.891)ng/ml,高于无脑血管病组的(3.235±2.294)ng/ml(P<0.01)。既往有脑血管病史的Tf为(391.44±222.28)pg/ml,明显高于无脑血管病史组(P<0.01)。结论急性脑梗死患者的血浆Tf浓度明显增高,血浆Tm浓度明显降低。血浆Tf浓度高,Tm浓度低预示病情严重。

Objective To investigate the plasma levels of Tf and Tm in acute cerebral infarction patients and their clinical significance. Methods the tissue factor and thrombomoduhn levels were measured with ELISA in 76 patients with acute cerebral infraction and 47 healthy subjects as control group. Results The plasma level of Tf was significandy higher in patients with acute cerebral infraction （384.06 ± 179.68, P〈0.01 ） than that in the control group （83.254±32.978）. The plasma level of Tm was significantly lower in acute cerebral patients （2.899 ±2.901, P〈0.0 5 ）than that in the control group （3.921±1.384）. The plasma Tf level significantly was increased in the patients with serious cerebral infarction and High-Grade atherosclerosis and previous vascular history. Conclusions It is demonstrated that the plasma level of Tf was increased and the plasma level of Tm was decreased in acute cerebral infarction patients. Whereas these may predict a serious vascular disease.