摘要
甘草次酸(glycyrrhetinic acid,2)是从豆科植物甘草的根茎中提取得到的五环三萜类化合物。药理活性研究表明:2的3-羟基被取代后,其抗炎活性、抗溃疡活性较为显著,且3、30-位分别成酯后具有较高的抗炎活性。
N-Acetyl glycine-glycyrrhetinic acid ester was synthesized by N-acetyl glycine and glycyrrhetinic acid in CH2Cl2 in the presence of DCC/DMAP under three different conditions respectively: stirring at 18℃, refluxing at 40℃, refluxing at 40℃ under ultrasonic radiation. The reaction speed of esterification was detected by HPLC. The results showed that the yield of ester was higher under the last condition in shorter reaction time.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2006年第4期232-233,251,共3页
Chinese Journal of Pharmaceuticals
基金
科技部863计划博士基金项目(2003AA2Z3534)