咪达唑仑治疗难治性惊厥持续状态29例

Midazolam treats the twenty-nine childrens with refractory generalized convulsive status epilepticus

目的:研究咪达唑仑治疗难治性惊厥持续状态的疗效及临床价值。方法:对29例难治性惊厥持续状态患儿首先给予咪达唑仑负荷量0.2mg/(kg.次),30min后给予维持量1.0μg/(kg.min),每30min增加维持剂量1.0μg/(kg.min)直到惊厥停止。结果:29例患儿中26例在咪达唑仑维持量8.0μg/(kg.min)内惊厥停止,未发现明显不良反应。结论:咪达唑仑是治疗难治性惊厥持续状态的安全、有效的药物。

Objective： To study the efficacy and clinical value of midazolam in treating refractory generalized convulsive status epilepti- cus. Methods： The twenty-nine children of refractory generalized convulsive status epilepticus were, first, given a charge of midazolam of 0.2 mg/kg. After half an hour, a maintenance dose of 1.0 μg/（kg·min） was added, and then a dose of 1.0 μg/（kg·min） was added every 30 minutes until the convulsion stopped. Results： Conversion stopped in 26 cases when less than maintenance doses of 8.0μg/（kg·min） of midazolam were used and no side effect was found. Conclusions： Midazolam is a safe and effective medicine in treating refractory generalized convulsive status epilepticus.