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CD34在外阴病变组织中的表达 被引量:3

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摘要 目的探讨外阴真皮组织内血管形成及密度改变与外阴皮肤黏膜上皮内非瘤样病变(NNEDV)及外阴上皮内瘤变(VIN)的关系。方法2000年1月至2005年1月对沈阳市妇婴医院等采用免疫组织化学链菌素抗生物素———过氧化物酶(SP)法,检测人原始造血细胞抗原(CD34)在外阴病变组织中的表达。结果在外阴硬化性苔藓(VLS)组织中微血管密度(MVD)值为10.10,在VIN组织中MVD值为32.70,两者与正常皮肤(NS)比较差异均有显著性意义(P<0.05)。在外阴鳞状上皮增生(VSH)组织中MVD值为22.84,3种病变中任意两组比较差异均有显著性意义(P<0.05)。结论MVD在VLS真皮中表达较NS、VSH和VIN低,提示VLS组织存在真皮微循环障碍。在VIN中MVD值较VSH高,提示MVD增加加速了异型细胞的增殖。
出处 《中国实用妇科与产科杂志》 CAS CSCD 北大核心 2006年第4期283-284,共2页 Chinese Journal of Practical Gynecology and Obstetrics
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  • 1EL-Assal ON,Yamanoi A,Soda Y,et al.Clinical significance of microvessle density and vascular endothelial growth factor expretion in hepatocellular carcinoma and surrounding liver:possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liver[J].Hepatology,1998,27 (6):1554-1562.
  • 2Yoshida H,Fujita S,Nishida M,et al.Angiogenesis in the human temporomandibular joint studied by immunohistochemistry for CD34 antigen[J].J Oral Pathol Med,1999,28 (7):289 -292.
  • 3卓贤露,宋宇峰.口腔鳞癌组织中bFGF的表达与血管生成的关系[J].实用口腔医学杂志,2005,21(3):303-306. 被引量:14
  • 4Nijsten T,Colpaert CG,Vermeulen PB,et al.Cyclooxygenase-2expression and angiogenesis in squamous cell carcinoma of the skin and its precursors:a paired immunohistochemical study of 35cases[J].Br J Dermatol,2004,151 (4):837-845.

二级参考文献8

  • 1Kos M, Dabrowski A. Tumour's angiogenesis:The function of VEGF and bFGF in colorectal cancer. Ann Univ Mariae Curie Sklodowska[Med],2002,57(2):556.
  • 2Weidner N. Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol,1995,147(1):9.
  • 3Azuma M, Yuki T, Motegi K,et al. Enhancement of bFGF export associated with malignant progression of human salivary gland cell clones. Int J Cancer,1997,71(5):891.
  • 4Myoken Y, Myoken Y, Okamoto T,et al. Immunohistochemical localization of fibroblast growth factor-1 (FGF-1) and FGF-2 in cultured human ameloblastoma epithelial cells and ameloblastoma tissues. J Oral Pathol Med,1995,24(9):387.
  • 5Sako A, Kitayama J, Yamaguchi H,et al. Vascular endothelial growth factor synthesis by human omental mesothelial cells is augmented by fibroblast growth factor-2:Possible role of mesothelial cell on the development of peritoneal metastasis. J Surg Res,2003,115(1):113.
  • 6Cronauer MV, Schulz WA, Seifert HH,et al. Fibroblast growth factors and their receptors in urological cancers:Basic research and clinical implications. Eur Urol,2003,43(3):309.
  • 7张庆元,李金荣,李武修,吴淑华,吕增华,孙小云.口腔鳞状细胞癌血管内皮细胞生长因子的表达[J].实用口腔医学杂志,2003,19(4):362-365. 被引量:7
  • 8李冬梅,崔永兴,董福生.牙龈癌微血管密度及血管内皮生长因子表达的意义[J].实用口腔医学杂志,2004,20(1):66-69. 被引量:7

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