反复呼吸道感染患儿铁营养状况及其与血清IgG亚类、T细胞亚群关系的探讨

RELATIONSHIP BETWEEN NUTRIENT STATE OF IRON AND SERUM IMMUNOGLOBULIN G SUBCLASSES,SUBSETS OF T LYMPHOCYTE IN CHILDREN WITH RECURRENT RESPIRATORY TRACT INFECTION

检测４７例ＲＲＴＩ患儿铁营养状况、外周血Ｔ细胞亚群、血清ＩｇＧ亚类等。结果表明，ＲＲＴＩ患儿缺铁发生率为７８．７２％，其中约％为隐性缺铁；ＲＲＴＩ组ＣＤ＋４细胞百分率、Ｔ细胞增殖功能明显降低，血清ＩｇＧ亚类缺陷检出率为３６．１７％，以ＩｇＧ４，ＩｇＧ１缺陷居多。ＳＦ、ＦＥＰ与ＣＤ＋４细胞、ＩｇＧ亚类间存在显著相关关系。提示ＲＲＴＩ多伴有铁营养不足；铁缺乏可能通过损害Ｔｈ细胞功能而导致ＩｇＧ亚类缺陷，引起ＲＲＴＩ发作。

Nutrient state of iron,serum immunoglobulin(Ig)G subclasses and subsets of T lymphocyte were measured in 47 children with recurrent respiratory tract infection (RRTI).In RRTI group,the rate of iron deficiency was 78.72%,and 2/3 of which were latent iron deficiency and percentage of CD+4 cell,T lymphocyte proliferative function were decreased.The frequency of IgG subclass deficiency was 36.17% in RRTI children and IgG4,IgG1,deficiency were common deficient types.A corelationship between serum ferritin(SF),free erythocyte porphyria(EEP)and percentage of CD+4 cell,IgG subclasses were observed in RRTI children.These results suggest that many of RRTI children may be in company with iron deficiency that injured the function of T helper cell and caused IgG subclass deficiency in children with RRTI.