口腔颌面部肉瘤中hTERT蛋白的表达

The Expression of hTERT Protein in Oromaxillofacial Sarcoma

目的探讨口腔颌面部肉瘤中hTERT蛋白表达的生物学意义。方法应用免疫组化方法检测37例口腔颌面部肉瘤和14例良性间叶组织肿瘤中hTERT蛋白的表达情况。结果口腔肉瘤中hTERT蛋白的阳性表达率明显高于良性肿瘤(P<0.05),并随肉瘤分化程度的降低而呈升高趋势,其中低度恶性肉瘤与高度恶性肉瘤比较差异有统计学意义(P<0.05)。hTERT蛋白表达与肉瘤复发密切相关(P<0.05),发生淋巴结转移或远处转移的肉瘤中hTERT蛋白表达虽明显升高,但无统计学意义(P>0.05)。结论hTERT蛋白表达与口腔颌面部肉瘤的临床病理特征密切相关,表明hTERT基因在口腔颌面部肉瘤发生发展过程中可能起重要作用。

Objective To investigate the biological significance of the expression of hTERT protein in oromaxillofacial sarcoma. Methods In application of immunohistochemically 51 diagnosed specimens of 37 sarcomas and 14 benign mesenchymal tumors from oral and maxillofacial regions, the expression of hTERT protein was determined by immunohistochemistry. Results The expression level of hTRET protein was significantly increased in sarcomas compared with benign tumors （ P 〈 0.05）, and tended to increase with pathological grades. There was a significant difference between sarcomas of low grade and high grade （ P 〈 0.05）. The hTERT expression was closely associated with presence of local recurrence （ P 〈 0.05）. The expression of hTERT protein increased in sarcomas with distant and（or） lymph node metastasis, but the results showed no significant difference between the sarcomas with and without distant metastasis or lymph node metastasis （ P 〉 0.05）. Conclusions The expression of hTERT protein was closely correlated with the clinicopathological characteristics of oromaxillofacial sarcoma, suggesting that the hTERT gene may play an important role in tumorigenesis and develonment of oromaxillofacial sarcoma.