胰岛素样生长因子-1在胎儿生长中的重要作用

The Insulin-like Growth Factor-1 is Important for Fetus' Growth

目的检测孕产妇、新生儿胰岛素样生长因子-1(Insu lin-like grow th factor-I,IGF-1),探讨小于胎龄儿及宫内发育迟缓儿的发病机制。方法采用放射免疫法检测血清中IGF-1。比较小于胎龄儿与足月胎龄儿,早产孕妇和正常足月孕妇IGF-1含量,了解不同体重、不同胎龄、不同胎盘成熟胎儿及其孕妇母体的IGF-1水平差异。结果IGF-1随胎龄、胎重的增加而增高。表明IGF-1在胎儿生长发育中的重要调节作用。早期改善母体营养,达到改善胎儿宫内营养状况。结论在孕早、中期及时检测IGF-1含量,预防胎儿宫内发育迟缓,产前提高胎儿整体健康水平。

Objective Measure the insulin-like growth factor-1 （IGF-1） in pregnant women and newborns ,to investigate the mechanism of small for gestational age （SGA） and intrauterine growth retardation（IUGR）. Methods The serum IGF-1 was measured by RIA. Comparing the level of IGF-1 in SGA with that in normal gestational age and understanding the difference of IGF-1 level among fetus with different weight,gestational age,mature of placenta. Results The IGF-1 increase with gestational age and weights increasing. Conclusion IGF-1 is very important for fetus＇ growth. Early improve the pregnant women＇s nutrition to improve fetus intrauterine nutrition,prevent IUGR,improve fetus health before delivery.