龙虎芪黄汤对小鼠化学性肝损伤的保护作用

Protective Effect of Longhu Qinhuang Decoction on Chemical Injury of Liver in Mice

观察龙虎芪黄汤对四氯化碳(CCl4)、D-半乳糖胺(D-GaIN)所致小鼠急性化学性肝损伤影响,结果表明龙虎芪黄汤可显著降低由CCl4、D-GaIN所致小鼠血清ALT、AST及肝组织MDA的升高,明显提高肝组织SOD的含量,能明显改善CCl4、D-GaIN所致的肝组织病理学损伤,而对肝组织NO、TNF-α含量则无明显影响。说明龙虎芪黄汤对CCl4、D-GaIN所致小鼠急性化学性肝损伤可起到保肝降酶、抗脂质过氧化等作用。

To observe the effect of longhu qinhuang decoction on the chemical injury of liver induced by carbon tetrachloride （CCl4） and D-galactosamine （D-GaIN） in mice. The result showed that longhu qinhuang decoction could significantly reduce the levels of serum ALT, AST, decrease MDA and increase SOD of liver tissue, and ameliorate the pathological injure of liver, but had not obvious effect on the contents of NO and TNF-α of liver tissue. Pretreatment with longhu qinhuang decoction could protect the mice from chemical injury of liver, the mechanisms may be related to inhibiting lipid peroxide and production of ALT, AST, etc.