核素心室显像对缬沙坦治疗原发性高血压患者左心室功能影响的研究

The studies of effect on cardiac functions in patients with essential hypertensionoraling Valsartan by equilibrium radionuclide angiocardiography

目的利用核素心室显像,探讨血管紧张素II受体拮抗剂——缬沙坦对原发性高血压患者左心室功能的影响。方法本研究入选原发性高血压患者72例,随机分配(1:1)到缬沙坦(口服80～160mg/d)组或阿替洛尔(口服25～50mg/d)组,治疗8个月,治疗前后各行一次核素心室显像检查,对比分析组内治疗前后左心功能参数变化和两组间的差异。结果与治疗前比较,原发性高血压患者在缬沙坦或阿替洛尔治疗8个月后,两组收缩压与舒张压明显下降(159/101～142/89mmHg;161/103至140/90mmHg()P<0.01);左室舒张功能(以左室峰充盈率代表)明显改善(P<0.05),而在阿替洛尔治疗后8个月后左室高峰充盈率无明显的变化,两组间比较有明显的变化(P<0.05)。结论原发性高血压患者在缬沙坦治疗8个月后可使原发性高血压患者左心室舒张功能显著改善,对左心室舒张功能的作用优于阿替洛尔。

Objective To explore the effect of angiotensin Ⅱ antagonist valsartan on left ventricular function in patients with essential hypertension by equilibrium radionuclide angiocardiography. Methods 72 patients with essential hypertension by radionuclide angiocardiography entered the study. Patients were randomized into the valsartan （80-160mg/d）group or atenolol （25-50mg/d） group for 8 months. The radionuclide angiocardiography before and after 8 months of treatment with valsartan or atenolol were examined. Results Data were analyzed and showed that： ①After 8 months of treatment with valsartan or atenolo, blood pressure was reduced from 159/101 to 142/89 mmHg（P〈0.01） or from 161/103 to 145/90 mmHg（P〈0.01） respectively.②LVPFR improved from 1,87 to 2,59（P〈0,05） in valsatan but no change found in atenolol. Conclusion Long-term treatment with valsartan resulted in a significant improvement of left ventricular diatolic function in patients with essential hypertension, and valsartan was much better than atenolol for left ventricular diatolic function.