拉西地平治疗原发性高血压的疗效及其耐受性

CLINICAL OBSERVATION ON THE EFFICACY OF LACIDIPINE IN TREATMENT OF ESSENTIAL HYPERTENSION

采用随机、双盲、组间平行安慰剂对照的方法对129例轻、中度高血压患者进行6周治疗观察。结果示拉西地平组(1次/d,4～6 mg/次)的降压有效率明显高于安慰剂组(76.7%对23.4%,P<0.01),平均坐位血压由20.9/13.2 kPa(156.4/98.9 mmHg)降至18.0/11.4 kPa(135.1/87.7 mmHg)(P<0.01),患者的生活质量也获得明显改善。拉西地平不良反应发生率与安慰剂近似(19.4%对15.6%)。

A randomized,double blind,and parallel study was conducted in 129 pa- tients with mild to moderate essential hypertension,using a once daily dose of 4～8mg lacidipine or placebo for 6 weeks.The results showed that the effective rate of lacidipine group was significantly higher than that of placebo group(76.7% vs 23.4%,P<0.01)and the mean blood pressure of the active group was droped from 20.9/13.2 kPa(156.4/98.9 mmHg)to 18.0/11.7 kPa(135.1/87.7 mmHg)(P<0.01).The incidence of side effects are similar in the two groups.Therefore,lacidipine is a safe,effective,and convenient antihy- pertensive.