糖克煎剂对糖尿病大鼠肾脏病理组织结构的影响

Tang Ke Decoction to Kidney Pathological Effect of Diabetic Nephropathy Rat

目的:观察并探讨具有祛痰化瘀作用的中药复方糖克煎剂对实验性糖尿病大鼠肾脏结构的影响。方法:雄性W istar大鼠78只,一组予普通饲料喂养,其余5组予高糖高脂饲料喂养,1个月后经尾静脉1次性注射链脲佐菌素(STZ)造成糖尿病及痰浊血瘀中医证候模型。应用具祛痰化瘀作用的中药复方糖克煎剂分别在造模成功及成模后4周灌胃给药,并设立洛汀新组为西药对照组,观察大鼠肾脏的病理组织学变化。结果:糖克煎剂能够减轻肾脏肥大及肾小球系膜基质增生、硬化,糖克预防组疗效优于糖克治疗组。结论:中药复方糖克煎剂能够预防和治疗大鼠早期糖尿病肾病,其机制可能与延缓肾脏的病理组织损害有关。

Objective ： To investigate and explore the effect of traditional Chinese medicine complex prescription - Tang Ke Decoction on early kidney pathological changes in experimental diabetic rat. Methods. 78 male Wistar rats were divided into seven groups randomly. Rats in one group were given common forage. Rats in the other five groups were given high fat forage and were injected streptozotocin in vena caudalis once after one month to make diabetes and the blood stasis and phlegm syndromes in TCM modal. Tang Ke Decoction with expelling phlegm and activating blood circulation was lavaged separatedly after success model and 4 weeks after success model. Luo Ting Xin group was control group of western medicine. The pathological changes of kidney were observed. Results： Tang Ke Decoction can lighten kidney hypertrophy and the renal glomerulus mesenterium ground substance hyperplasia and sclerosis;Tang Ke prevention group had obvious curative effect compared to tang Ke treatment group,which had significant difference. Conclusion ： Chinese medicine complex prescription - Tang Ke Decoction can prevent and cure early diabetic nephropathy of rat which may have relationship with delaying the damages of kidney pathological changes.