脂质体肝素透皮吸收的初步观察

Preliminary Observation on Percutaneous Absorption of Liposomal Heparin

以脂质体肝素5 000 u、10 000 u喷雾于12名健康自愿者皮肤上,给药后30 min、90min,凝血酶凝固时间（TCT）比给药前延长,统计学处理有显著差异（P<0.01～0.001）,同时,12例中5例诉性功能增强。结果表明,本试验所用的脂质体肝素,通过开放式给药,可以穿透皮肤,进入血循环,产生抗凝效果。

Liposomal heparin of 5 000 u and 10 000 u was sprayed onto the skin of 12 healthy subjects. Thrombin clotting time prolonged markedly 30-90 min after heparin application. In comparison to before spraying liposomal heparin, the difference was significant statistically (P<C0. 01 -0. 001). Furthermore, inceased sexual activity occurred in 5 out of 12 subjects. The results showed that liposomal heparin used, through open application can penetrate into human skin and blood circulation, and cause anticoagulant action.