危重病患者血浆β内啡肽测定及其临床意义

Determination of plasma βendorphin in critically ill patients and its clinical significance

用放射免疫法测定了１８例健康人及２６例危重休克患者血浆β内啡肽（βＥＰ）浓度。结果表明：危重休克患者血浆βＥＰ水平显著高于正常对照组（βＥＰ分别为２１０１．３４±１０９０．６３ｎｇ／Ｌ和５３６．５５±２８１．４５ｎｇ／Ｌ），Ｐ＜０．０１。血浆βＥＰ含量升高的程度与危重休克患者血压降低呈负相关，Ｐ＜０．０５。１４例危重休克患者静脉注射纳络酮１小时后，血压升至正常，血浆βＥＰ含量亦显著下降，与正常对照组比较无显著差异（Ｐ＞０．０５）。结果提示：血浆βＥＰ含量升高在休克病理过程中起重要作用，纳络酮具有较好的抗休克效应。

lasma level of βendorphin was determined in 26 critically ill patients and 18 normal adults by radioimmunoassay.It was found that plasma level of βendorphin was significantly higher in critically ill patients than in the controls( P <0 01),The increase of plasma βendorphin was negatively correlated with the decrease of blood pressure( P <0 05).One hour after intravenous injection of naloxone in 14 critically ill patients with shock,their blood pressure returned to normal and their plasma βendorphin was significantly decreased and not significantly different from that of the controls( P >0 05).Our findings suggest that the increased plasma level of βendorphin plays an important role in the development of shock and naloxone possesses excellent antishock effect.