急性脑血管病患者血清和脑脊液三碘甲状腺原氨酸、甲状腺素及促甲状腺激素含量的变化及其临床意义

Changes and signiticances of T 3,T 4and TSH in serum and cerebrospinal fluid in patients with acute cerebrovascular disease

对６５例急性脑血管病（ＡＣＶＤ）患者血清与脑脊液（ＣＳＦ）中三碘甲状腺原氨酸（Ｔ３）、甲状腺素（Ｔ４）及促甲状腺激素（ＴＳＨ）的含量进行了测定，发现脑出血组与脑梗塞组血清与ＣＳＦ中Ｔ３、Ｔ４明显低于正常对照组（Ｐ均＜０．０１），ＴＳＨ则明显高于对照组（Ｐ＜０．０５）；且脑出血组Ｔ３、Ｔ４明显低于脑梗塞组，ＴＳＨ则高于脑梗塞组；病情轻重与甲状腺激素的变化明显相关（Ｐ＜０．０５）；治疗前后甲状腺激素水平明显不同，治疗后Ｔ３、Ｔ４明显升高（Ｐ均＜０．０５），以Ｔ３升高最明显（Ｐ＜０．０１）。作者并就其改变机制及临床意义进行了初步讨论。

Concentrations of T 3,T 4 and TSH in serum and cerebrospinal fluid(CSF) in 65 patients with acute cerebrovascular disease were determined.T 3 and T 4 in serum and CSF were significantly lower in the group of cerebral hemorrhage and the group of cerebral infarction than in the control group,while TSH was significantly higher in the former two groups than in the latterone.T 3 and T 4 were significantly lower in the group of cerebral hemorrhage than in the group of cerebral infarction,while TSH was higher in the former two groups than in the latter one.The severity of the disease was significantly correlated with the changes of thyroid hormones( P <0.05).The levels of thyroid hormones before and after treatments were obviously different;T 3 and T 4,especially T 3,were markedly increased after treatments( P <0.01).The mechanism and the clinical significance of the changes were discussed.