山茱萸的免疫药理活性

IMMUNOPHARMACOLOGIC ACTIONS OF CORNUSO OFFICNALIS

比较山茱萸生药和炙药水煎剂体外抑制淋巴细胞有丝分裂反应及混合淋巴细胞反应的效应。二种药物均有强抑制活性，药物浓度３ｍｇ／ｍｌ就可抑制８５％以上的反应，二者没有明显的差别。小鼠口服水煎剂，淋巴细胞产生ＩＬ－２也降低。此外，口服山茱萸水煎剂，可将小鼠移植心脏存活时间由８．１±１．６ｄ延长到１２．９±３．１ｄ。结果显示山茱萸是一种免疫抑制性药物。

The actions of decoctions of raw and broiled Cornus omcinalis on lymphocyte mito-sis and mixed lymphocyte reaction(MLR)were studied and compared.Both of them had strong suppresive actions on PHA,ConA,LPS or PWM-induced mitosis and MLR,These could be suppressed for more than 85% when the doses were beyond 3 mg/ml.Interleukin 2 production from lymphocytes was decreased after orally administered Cornus officinalis decoc-tion.Moreover,the survival span of transplanted mouse hearts was prolonged from 8.1±1.6 days to 12.1 days after oral administration of the decoction.These results indicated that Cornus officinalis was an immunosuppressive herb.