摘要
环氧合酶是催化花生四烯酸合成前列腺素类的第一步关键酶,许多实体瘤中都有环氧合酶-2(COX-2)的高表达,COX-2的高表达与肿瘤的生长、转移、放化疗抗拒有关,本文综述了选择性COX-2抑制剂增加放疗敏感性的可能作用机制及研究进展。
The COX-2 enzyme is the key enzyme of the first step in catalyzing arachldonic acid into prostanoid, which is frequently overexpressed in many solid tumors .The high expression of the eyclooxygenaac-2 （COX-2） enzyme is related to the growth, metabasis and Iesistance to radiotherapy. This article reviews the mechanism and progress of selective COX-2 inhibitor, in promoting radiotherapeutic sensitivity. These findings have led to the intensive study of statins in radiotherapy with selective COX-2 inhibitor.
出处
《医学综述》
2006年第8期495-496,共2页
Medical Recapitulate
