神经系统副肿瘤综合征34例临床特点分析

Clinical characteristics of 34 cases with paraneoplastic neurological syndrome

目的:分析34例神经系统副肿瘤综合征患者的临床特点。方法:对1990年至2005年收治的34例神经系统副肿瘤综合征患者的临床资料进行回顾性分析。结果:副肿瘤综合征的临床类型有周围神经病15例、Lambert-Eaton肌无力综合征5例、多发性肌炎和皮肌炎3例、进行性小脑变性2例、运动神经元病3例、进行性多灶性白质脑病1例、亚急性坏死性脊髓病1例、脑干脑炎2例、边缘系统脑炎2例。结论:神经系统副肿瘤综合征临床表现形式多样,容易误诊,临床早期确诊对于隐匿肿瘤的发现和治疗非常重要。

Objective： To investigate the clinical characteristics of 34 patients with paraneoplastic neurological syndromes. Methods： we analyzed the clinical data of 34 patients diagnesed as paraneoplastic neurological syndromes from 1990 to 2005 retrospectiveiy. Results： clinical symptoms： peripheral neuropathy was observed in 15 subjects, Lambert-Eaton＇ s myasthenia syndromes in 5 subjects, poly myositis or dermatomyositis in 3 subjects, progressive cerebellar degeneration in 2 subjects, motor neuron disease in 2 subjects, progressive multifocal leukoencephalopathy in 1 subjects , subacute necrotic myelopathy in 1 subjects, brain stem encephalitis in 2 subjects , IAmbic encephalitis in 2 subjects. Conclusion： The manifestations of PNS were too complicated to be misdiagnostics easily in clinical work, so the early diagnosis is useful to treatment of the underling tumor.