无症状性脑梗塞患者脑血流灌注的相关研究

Study of Cerebral Circulation in Slient Cerebral Infarction

目的:探讨无症状性脑梗塞(Slient Cerebral lnfarction,SCl)患者的脑血流灌注状况,确定监测病情变化的有效手段。方法:采用Diamox药物负荷,99mTc-ECD SPECT核素显像技术,对20例SCI患者及15例正常对照组进行静态时及负荷后脑血流定量测定。结果:1、静态显像时,SCI组大脑平均脑血流量、额、颞、顶叶皮质及基底节区局部脑血流较对照组轻度降低(P<0.05),负荷后与对照组相比血流降低更加明显(P<0.01);2、危险因素种类个数与SCI患者平均脑血流变化呈有意义的负相关(r=-0.5648,P<0.05)。结论:SCI患者脑血流灌注处于低下状态,脑血管代偿能力降低;2、危险因素的累积作用进一步降低SCI患者的血流灌注;负荷脑血流定量检测技术能客观地反映SCI的脑循环动态情况,可作为有效的病情监测手段。

Objective： To establish a practical way of monitoring progression in silent cerebral infarction （SCI） by meausuring cerebral blood flow（CBF） quantitatively. Method： 20 patients of SCI and 15 normal age mathed subjects were investigated by measurement of CBF pre-and post-Diamox administration using 99mTc-ECD consecutive SPECT. Result： l/The rest mCBF （mean cerebral blood blow） ,1：he rest rCBF （regional cerebral blood flow） in the frontal ,temporal, pa- rietal, occipital and besal ganglia cortex of SCI group decreased slightly compared with those of the normal subjects （P〈 0.05）. The whole CBF was further lower significantly after Diamox stress （P〈0.01）. 2/The numbers of the risk factor are significantly negative correlated with the mCBF of SCI group（r=0. 5648 P〈0.05）, Conclusion,. The patient of SCI has a hypoperfusion and damaged CRC（ cerebral reserve capacity） The effect of cumulative risk factors may deteriorate the decreased CBF in patients with SCI . The measurement of CBF pre and post- Diamox can monitor the situation of the patients with SCI in different stages, It is effective way to monitor the progression in diseases.