北京地区部分儿童血脂现状调查及气体分子硫化氢在血脂紊乱中的变化

Survey of plasma lipid value in children in Beijing area and the changes of gaseous molecule-hydrogen sulfide in the ones with dyslipidemia

目的:通过对北京地区部分儿童血脂调查,评价其现况水平;并探讨血脂紊乱儿童血浆硫化氢(H2S)水平的变化及其与血脂成分的关系。方法:随机选取7-18岁北京市中小学生共971人,生源来自北京市区县。根据年龄及性别将其分为4组(学龄期男、女组;青春期男、女组),通过对身高、体重的测量,计算出体重指数(body mass index,BMI),并进行家族史、现病史与既往史的调查及体格检查;应用日立7060型全自动生化分析仪检测其空腹血浆丙氨酸氨基转移酶(alanine aminotransferase,ALT),总胆固醇(total cholesterol,TC),甘油三酯(triglyceride, TG),高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)及低密度脂蛋白胆固醇(low density lipopro- tein cholesterol,LDL-C)水平。并自上述人群随机抽取血脂紊乱儿童(血脂紊乱组)40例(男31例,女9例)以及血脂正常儿童(血脂正常组)60例(男38例,女22例),应用敏感硫电极法测定血浆H2S水平。结果:971名儿童中, 筛查出血脂紊乱患者共91例(男58例,女33例),患病率为9．37％(91／971);血脂紊乱与血脂正常儿童BMI相比较,前者肥胖指数明显升高,差异有统计学意义;肝功能异常(ALT增高)与儿童血脂紊乱有关。100例儿童血浆 H2S水平呈偏态分布,以中位数(上、下四分位数间距)表示,血脂紊乱组儿童血浆H2S含量为34．40(32．98, 35．47)μmol／L,血脂正常组儿童血浆H2S含量为38．81(36．53,40．66)μmol／L,血脂紊乱组H2S水平明显降低(P <0．01);总体男生血浆H2S水平为35．54(33．41,39．24)μmol／L,女生H2S水平为37．82(33．84,39．80)μmol／L, 性别组间比较差异无统计学意义(P>0．05)。结论:北京地区儿童血脂紊乱的患病率较高;血脂紊乱儿童血浆硫化氢水平明显降低,新型气体信号分子硫化氢与血脂紊乱儿童的血脂成分异常具有明显相关性。

Objective：To evaluate plasma lipid value in children in Beijing areas and to explore the relationship between plasma hydrogen sulfide （H2S） level and lipid components. Methods： A total of 971 healthy school students were chosen randomly, all coming from Beijing city and its counties. They were divided into four groups according to their gender and age （boys and girls in school age and in puberty）. Body mass index （BMI） was calculated according to the measurement of body height and weight. Familial history, past medical history and the history of present illness were investigated. Physical examination was also carried on. Alanine aminotransferase （ALT）, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein-cholesterol （HDL-C） and low density lipoprotein-cholesterol （LDL-C） were detected by HITACHI 7060 automatic biochemical analyzer. Forty children （31 males and 9 females） with dyslipidemia were chosen randomly among them as patients. Other 60 children （38 males and 22 females） with normal plasma lipid level served as controls. Plasma H2S level was detected by modified sulfide electrode. Results： There were 91 children with dyslipidemia （58 males and 33 females） in 971 students. The prevalence rate was 9.37%. The average value of BMI in patients was higher than that of controls. An association of increased ALT level with the prevalence of dyslipidemia was observed. Hydrogen sulfide concentration in plasma showed out skew distribution. Measurement data were presented as median（ P25, P75 ）- Hydrogen sulfide was 3 4.40 （ 32.98,35.47 ） μmol/ L in children with dyslipidemiaand3 8.8 1（36.53,40.66） μmol/L in controls. There was statistical difference between the two groups （P 〈 0.01 ）. Average value of plasma hydrogen sulfide was 35.54 （ 33.41,39.24 ） μmol/L in males and 37.82 （33.84,39.80） μmol/L in females. There was no difference in plasma hydrogen sulfide between male and female subjects （P 〉 0.05）. Conclusion： The prevalence rate of dyslipidemia in Beijing children is relatively high as compared with what it was during the past several decades There was a significant decrease in plasma endogenous H2S level in children with dyslipidemia as compared with that of healthy children. There was an obvious correlation between plasma hydrogen sulfide and plasma lipids.