Survivin、Bcl-2和VEGF在骨髓增生异常综合征中的表达及其相关性

Expressions of Survivin, Bcl-2 and VEGF in Patients with Myelodysplastic Syndrome and Their Relationship

本研究探讨存活蛋白(survivin)在骨髓增生异常综合征(MDS)发病中的可能作用及寻找凋亡和血管新生两种不同的机制在MDS中可能存在的联系。采用免疫细胞化学的方法检测survivin、Bcl-2和VEGF在MDS低危、高危患者和AML患者及对照者骨髓中的单个核细胞的表达情况,并分析三者间的关系。结果表明:survivin、Bcl-2和VEGF在MDS低危组、高危组和AML组的表达率和积分均逐渐增高,除Bcl-2在MDS低危组和对照组的差异无统计学意义外(P>0.05),三者在各组间的表达差异均有统计学意义(P<0.05),且三者间的表达率均呈正相关关系。结论:survivin、Bcl-2和VEGF参与了MDS的发病并与疾病病程进展有关,凋亡异常和血管新生可能通过以上3种蛋白的相互作用在MDS的发病中存在着某种联系。

To determine the possible roles of survivin in the pathogenesis of myelodysplastic syndrome （MDS） and to explore the relationship between apoptosis and angiogenesis in MDS, the expressions of survivin, Bcl-2 and VEGF were detected in the BM cells of de novo patients with MDS, patients with AML and individuals of control by immunochemical staining and their relationship was analyzed, The results showed that the expression rate and integral of all the three proteins in the low-risk group of MDS, high-risk group of MDS and de novo acute myeloid leukemia patients gradually increased, in addition to expression of Bcl-2 in low-risk group of MDS and control group. The significant differences were observed in every two groups and there were positive relations between the every two proteins. It is concluded that survivin, Bcl-2 and VEGF are all involved in the pathogenesis of MDS, and related with the progression of this disease, the deregulated apoptosis and angiogenesis may be involved in the pathogenesis of MDS through interaction among three proteins mentioned above.