采用手术加辅助放疗的声门上型喉癌患者预后多因素分析

Multivariate analysis of prognosis of patients with supraglottic cancer who received operation and post-operative radiotherapy

目的:探讨影响接受手术+辅助放疗的声门上型喉癌患者预后的相关因素。方法:回顾性分析1992～2000年在中山大学肿瘤防治中心接受手术+辅助放疗的60例声门上型喉癌患者的临床病理资料,单因素分析采用KaplanMeier法,多因素分析采用Cox比例风险模型。结果:总的3年生存率为58.20%,5年生存率为44.30%。单因素分析显示临床分期、有无淋巴结转移、T分期及N分期是影响预后的因素。多因素分析提示有无淋巴结转移与临床分期是独立的预后因素。结论:有无淋巴结转移与临床分期是影响接受手术+辅助放疗的声门上型喉癌患者预后的独立因素。

OBJECTIVE： To explore the prognostic factors of patients with supraglottic cancer who received operation and postoperative radiotherapy. METHODS： Sixty patients were retrospectively reviewed from 1992 to 2000. Comparision between/among groups was performed by log-rank test. Multivariate analysis was carried out by Cox proportional hazard method. RESULTS： Overall 3- and 5-year survival rates were 58.20% and 44.30%. Univariate analysis indicated that clinical stage, Nstage, and lymph-node metastasis were the risk factors. Multivariate analysis showed that clinical stage and lymph-node metastasis were independent prognostic factors. CONCLUSIONS： Clinical stage and lymph-node metastasis are independent prognostic factors to patients with supraglottic cancer who received operation and post-operative radiotherapy.