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精索静脉曲张与生精细胞凋亡 被引量:13

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摘要 精索静脉曲张(VAC)是导致男性不育的常见原因,生精细胞凋亡在VAC所致的生精障碍中起了重要作用。VAC所致的少精子症是由于生精细胞广泛凋亡所致,其发生与镉毒性、氧化损伤、雄激素缺乏、睾丸温度升高、Fas/FasL作用增强等机制有关。而睾丸生精细胞凋亡检测虽有助于VAC手术指征的掌握及预后的判断,但属于创伤性检查,不宜作为临床常规。
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