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烷化剂类药物对睾丸生殖功能影响 被引量:2

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摘要 烷化剂类药物是常用抗肿瘤药物和免疫抑制剂,通过诱导生殖细胞凋亡,干扰精原干细胞(SSCs)自我更新增殖分化功能,最终导致无精子症或少精子症。同时也损伤生殖细胞遗传物质,导致子代遗传缺陷或畸形。烷化剂对睾丸生精功能损伤存在量效和时效关系,并与睾丸生殖细胞成熟阶段有关。烷化剂对生殖细胞损伤也表现出相应的内分泌变化。了解烷化剂损伤男性生殖功能的机制、影响因素以及临床评价或监测的内分泌指标,有利于临床早期监测并干预。
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