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雌激素对男性骨质代谢的影响 被引量:2

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摘要 雌激素在男性体内具有独特而不可替代的作用,男性骨代谢及骨质疏松与雌激素密切相关。男性各种骨细胞均表达雌激素的两种受体。雌激素参与调节男性长骨生长,保持松质骨量和完整性。雌激素受体的不同基因型也影响男性骨密度。干扰雌激素水平和雌激素缺乏或功能异常将导致男性的骨质代谢紊乱,并可导致骨质疏松。适当补充雌激素对缺乏雌激素的男性具有骨质代谢的良性作用。另外,雌激素还通过调节垂体生长激素(GH)的分泌发挥对男性骨骼的间接影响。但雌激素应用于男性骨质疏松的治疗还需要更多的研究和依据。
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