摘要
目的 比较丙泊酚靶控输注(TCI)静脉给药与手推静脉给药麻醉对无痛人流手术的影响。方法将220例人流术者随机分为2组,Ⅰ组:TCI泵推注丙泊酚,靶质量浓度设定为6—7mg·L^-1,维持时靶质量浓度设定为4-5mg·L^-1,手术结束时停止输药;Ⅱ组:静脉推注给药,丙泊酚诱导量2—2.5mg·kg^-1,手术期间追加丙泊酚50mg左右。分别观察2组诱导、苏醒时间、总药量、麻醉效果及诱导前后平均动脉压、心率、动脉血氧饱和度的变化。结果Ⅰ组诱导、苏醒时间、用药量均少于Ⅱ组(P〈0.01);2组诱导后平均动脉血压、心率、血氧饱和度均低于术前(P〈0.05),Ⅱ组下降更严重;麻醉效果Ⅰ组优于Ⅱ组(P〈0.05)。结论靶控输注丙泊酚麻醉用于人工流产手术可以减少麻醉用药量,缩短麻醉诱导、苏醒时间,有较好的麻醉效果。
AIM To compare the anesthetic effects of propofol by target-controlled infusion (TCI) by venous injection during painless artificial abortion. METHODS Two hundred and twenty patients scheduled for painless artificial abortion were randomly divided into 2 groups : TCI group (group Ⅰ ) and venous injection group (group Ⅱ ) . In groupⅠ , the anesthesia was induced dosage at 6 - 7 mg.L^-1 by TCI with propofol, maintained at 4 - 5 mg.L^-1, stopped injecting when operation end. In group Ⅱ: propofol was injected , induced dosage at 2 - 2.5 mg.kg^-1, propofol could be added about 50 mg during the operation . The induction time, recovery time , the total dose of propofol and anesthetic effects in 2 groups were compared . Mean arterial pressure(MAP), HR, arterial oxygen saturation(SaO2) were recorded before and after induction. RESULTS The induction time , recovery time and total dosage in group Ⅰ were all less than those in group Ⅱ (P 〈 0.01).MAP,HR and SaO2 after induction in 2 groups were all lower than those before induction (P 〈 0.05) , especially in group Ⅱ . The anesthesia effect was significantly better in group Ⅰ than in group Ⅱ (P 〈 0.05). CONCLUSION Target-controlled infusion propofol in painless artificial abortion can decrease the dose requirement of propofol, shorten the time of induction and recovery, increase anesthetic effect.
出处
《中国临床药学杂志》
CAS
2006年第2期102-104,共3页
Chinese Journal of Clinical Pharmacy
关键词
丙泊酚
靶控输注
人工流产
propofol
target-controlled infusion
artificial abortion