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免疫刺激序列对实验性变应性鼻炎EOTAXIN表达的影响 被引量：8

Effect of immunostimulatory sequence on the expression of EOTAXIN of experimental allergic rhinitis
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摘要 目的:探讨大鼠变应性鼻炎制模基础致敏阶段,给予CpGDNA(CpG1826)腹腔注射对其鼻黏膜EOTAXIN表达的影响作用。方法:在大鼠变应性鼻炎基础致敏阶段,腹腔注射卵清蛋白和氢氧化铝佐剂的同时,给予CpGDNA腹腔注射,观察其对模型形成的影响。观测指标包括症状得分、鼻黏膜局部嗜酸粒细胞表达以及鼻黏膜局部EOTAXIN表达情况。结果:CpGDNA应用后,变应性鼻炎模型症状减轻,鼻黏膜局部及骨髓中嗜酸粒细胞减少,鼻黏膜中EOTAXIN表达降低。结论:CpGDNA在基础致敏阶段应用对大鼠变应性鼻炎模型形成具有显著的干扰作用,其对鼻黏膜EOTAXIN表达的抑制可能为其作用机制之一。 Objective： To investigate the effect of CpG DNA applied intraperitoneally on the expression of EOTAXIN of allergic rhinitis model. Method：CpG DNA was injected intraperitoneally to rat at the same time of the basic intraperitoneal immunized. The symptoms, expression of eosin6phil（EOS） in nasal cavity and expression of EOTAXIN in the nasal mucosa were measured. Result： After the CpG DNA was applied, the symptom scores, eosinophil（EOS） in nasal cavity and expression of EOTAXIN were weaken. Conclusion：There was great reverse effect of CpG DNA on the foundation of rat model of experimental allergic rhinitis,suppression of EOTAXIN may be one of the mechanisms.
作者 陈建军 孔维佳 项济生
机构地区 华中科技大学附属协和医院耳鼻咽喉科
出处 《临床耳鼻咽喉科杂志》 CAS CSCD 北大核心 2006年第8期362-364,共3页 Journal of Clinical Otorhinolaryngology
关键词 免疫佐剂 鼻炎 变应性 趋化因子 嗜酸粒细胞 Immunostimulatory sequence, CpG DNA Rhinitis, allergic EOTAXIN
分类号 R765.21 [医药卫生—耳鼻咽喉科]
  • 相关文献

参考文献6

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二级参考文献12

  • 1[1]Sato Y, Roman M, Tighe H, et al. Immunostimulatory DNA se quences necessary for effective intradermal gene immunization. Science, 1996,273 ( 19 ): 352
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共引文献9

同被引文献57

  • 1徐志鸿,杨成章.Th1/Th2失衡与变应性鼻炎[J].临床耳鼻咽喉科杂志,2004,18(8):510-512. 被引量：49
  • 2章如新,江德胜,李兆基,周水淼,萧轼之,乔德彪.P物质能神经阻滞剂治疗变应性鼻炎的实验研究[J].中华耳鼻咽喉科杂志,1994,29(5):282-285. 被引量：72
  • 3汤葳,Albert Chan,Stanley Chik,Adrain Wu,邓伟吾.白细胞介素5受体α链在支气管上皮细胞BEAS-2B的表达[J].中华微生物学和免疫学杂志,2007,27(1):69-73. 被引量：2
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引证文献8

二级引证文献19

临床耳鼻咽喉科杂志
2006年 第8期

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